TITLE
Interspecies variations in response to topical application of selected zinc compounds.

AUTHOR
Lansdown AB

ORGANIAZATION
Charing Cross and Westminster Medical School, Department of Comparative Biology, London, UK.

SOURCE
Food Chem Toxicol 1991 Jan; 29 (1): 57-64

LANGUAGE OF ORIGIN
English

ABSTRACT
The dermal irritancy of six zinc compounds was examined in three animal models. In open patch tests involving five daily applications, zinc chloride (1% aqueous solution) was severely irritant in rabbit, guinea-pig and mouse tests, inducing epidermal hyperplasia and ulceration; aqueous zinc acetate (20%) was slightly less irritant. Zinc oxide (20% suspension dilute Tween 80), zinc sulphate (1% aqueous solution) and zinc pyrithione (20% suspension) were not overtly irritant, but induced a marginal epidermal hyperplasia and increased hair growth. Zinc undecylenate (20% suspension) was not irritant. Epidermal irritancy in these studies is related to the interaction of zinc ion with epidermal keratin. The compounds studied were not consistently bacteriostatic in the three species tested. (AUTHOR)

MJTR: Guinea Pigs. Mice. Rabbits. Skin DE. Zinc TO.

MNTR: Administration, Topical. Animal. Bacillus DE. Bacillus GD. Cell Division DE. Chlorides AD. Chlorides TO. Epidermis CY. Epidermis ME. Hair GD. Male. Mitotic Index. Patch Tests. Skin MI. Species Specificity. Staphylococcus epidermidis DE. Staphylococcus epidermidis GD. Streptococcus DE. Streptococcus GD. Zinc AD. Zinc PK. Zinc Oxide AD. Zinc Oxide TO. JOURNAL ARTICLE

RNUM: 0 (Chlorides); 1314-13-2 (Zinc Oxide); 7440-66-6 (Zinc); 7646-85-7 (zinc chloride)

GEOT: ENGLAND

IDEN: ISSN: 0278-6915. JOURNAL-CODE: F3U. ENTRY-DATE: 910409. JOURNAL-SUBSET: M X. IM-DATE: 9106.

ACCE: 91153738