TITLE
Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives.

AUTHOR
Kniewald Z; Zechner V; Kniewald J

ORGANIZATION
Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia.

SOURCE
Endocr Regul 1992 Mar; 26 (1): 47-51

LANGUAGE OF ORIGIN
English

ABSTRACT
The metabolism of testosterone in the rat ventral prostate, anterior pituitary, basal hypothalamus and amygdala was studied in vitro under the influence of vitamin B6 compounds. The influence of these compounds on the activity of 5 alpha-reductase (5 alpha-R), 3 alpha- and 17 beta-hydroxysteroid dehydrogenase (3 alpha-HSD, 17 beta-HSD) was determined for all the examined tissues. Pyridoxine hydrochloride significantly increased the activity of 5 alpha-R, 3 alpha- and 17 beta-HSD, but pyridoxal hydrochloride had an inhibitory influence on 5 alpha-R and showed no effect on 3 alpha-HSD activity at the prostate level. Male rat anterior pituitary, basal hypothalamus or amygdala incubated with pyridoxal phosphate and pyridoxal hydrochloride showed modified enzymatic activities. Pyridoxal hydrochloride showed an inhibitory effect on 5 alpha-R in the rat pituitary and basal hypothalamus as well as in the rat prostate. (AUTHOR)

MJTR: Hydroxysteroid Dehydrogenases AN. Pyridoxine PD.

MNTR: Amygdaloid Body EN. Amygdaloid Body ME. Animal. Hydroxysteroid Dehydrogenases ME. Hydroxysteroid Dehydrogenases PH. Hypothalamus EN. Hypothalamus ME. Male. Pituitary Gland, Anterior EN. Pituitary Gland, Anterior ME. Prostate EN. Prostate ME. Pyridoxal Phosphate PD. Rats. Rats, Inbred F344. Support, Non-U.S. Gov't. Support, U.S. Gov't, Non-P.H.S.. Testosterone ME. 17-Hydroxysteroid Dehydrogenases AN. 17-Hydroxysteroid Dehydrogenases ME. 3-Hydroxysteroid Dehydrogenases AN. 3-Hydroxysteroid Dehydrogenases ME. JOURNAL ARTICLE

RNUM: EC 1.1.- (Hydroxysteroid Dehydrogenases); EC 1.1.- (17-Hydroxysteroid Dehydrogenases); EC 1.1.- (3-Hydroxysteroid Dehydrogenases); 54-47-7 (Pyridoxal Phosphate); 57-85-2 (Testosterone); 65-23-6 (Pyridoxine)

GEOT: CZECHOSLOVAKIA

IDEN: JOURNAL-CODE: A73. ENTRY-DATE: 921218. JOURNAL-SUBSET: M. IM-DATE: 9302.

ACCE: 93043111